DM transmission: DM/DM x DM/DM = N/DM?

[miran]

I am not saying that other laboratories are not accurate, but if you would like some answers, I suggest to repeat the DM tests on the dogs through OFFA, and then request additional information from OFFA if the tests return the same and the results are conflicting.

I think if the first test where by Missouri University than it is no use to do it by OFA because the buildings are just a few blocks away( 11 min. apart) from each other and they work together.
Or do you mean that the tests where done somewhere else and so maybe for a checkup doing it by them??

[yukidomari]

Originally Posted by miran

I think if the first test where by Missouri University than it is no use to do it by OFA because the buildings are just a few blocks away( 11 min. apart) from each other and they work together.
Or do you mean that the tests where done somewhere else and so maybe for a checkup doing it by them??

Miran,

Missouri U/OFFA test is the same. Missouri U has given OFFA the license to use their proprietary tests.

Yes, if they were done elsewhere, perhaps do it through OFFA and then if the results are still conflicting, OFFA/Missouri U researchers should try to answer questions regarding this.

But for now since the tests do not appear to have been done through OFFA, the scientists at Missouri U cannot attempt to answer any questions in this situation.

[miran]

Originally Posted by yukidomari

Miran,

Missouri U/OFFA test is the same. Missouri U has given OFFA the license to use their proprietary tests.

Yes, if they were done elsewhere, perhaps do it through OFFA and then if the results are still conflicting, OFFA/Missouri U researchers should try to answer questions regarding this.

But for now since the tests do not appear to have been done through OFFA, the scientists at Missouri U cannot attempt to answer any questions in this situation.

As I understand the test where done by Laboklin so in that way I also advice to do the test again by OFA

[yukidomari]

But also, we must know whether the puppies of the litters were each individually confirmed to be from the purported parents, and not just 1 or 2 puppies and then assuming the rest must also be from the same litter.

[Rona]

Originally Posted by miran

As I understand the test where done by Laboklin so in that way I also advice to do the test again by OFA

Many CSVs have been DM tested by Daniela at Prague University. All results of vlcaks from Poland (+ Lithuania?, Slovakia?, etc.) tested in Prague fit precisely into the pattern (n/n, n/dm, dm/dm) which indicates high validity of the testing procedures.

I wonder what's the statistical probability that a couple of dogs from the same kennel underwent the mutation?

[yukidomari]

Originally Posted by Rona

Many CSVs have been DM tested by Daniela at Prague University. All results of vlcaks from Poland (+ Lithuania?, Slovakia?, etc.) tested in Prague fit precisely into the pattern (n/n, n/dm, dm/dm) which indicates high validity of the testing procedures.

I wonder what's the statistical probability that a couple of dogs from the same kennel underwent the mutation?

Sure, other labs may also be accurate, but if you want OFFA scientists to answer any questions, you have to have the tests done through them, since they don't confirm others' results on their patented test.

But I agree that perhaps there's nothing for OFFA scientists to answer, that the problem is somewhere else (and not the tests nor the mode of inheritance).

[michaelundinaeichhorn]

I don´t know if Missouri was the first to invent a test and it is normal, that different research groups invent their own tests and sell them to commercial labs. As Bern University told me is the used test based on the gene research of a Swedish group.
I don´t know which test Prag is using.
Laboklin has the official permission to do rabies-titers for the import into the EU, what means, it is a lab that fits extremely high standarts and the work is controled on regular basis.
All results I know of fit the results of the parents, so if there is unregularity the right thing to do would be to contact the lab, ask them for their advise, do some paternity tests and - if paternity is positivly stated - let the tests be confirmed by another lab.

Ina

[draggar]

Originally Posted by Rona

Many CSVs have been DM tested by Daniela at Prague University. All results of vlcaks from Poland (+ Lithuania?, Slovakia?, etc.) tested in Prague fit precisely into the pattern (n/n, n/dm, dm/dm) which indicates high validity of the testing procedures.

I wonder what's the statistical probability that a couple of dogs from the same kennel underwent the mutation?

Other factors will need to be looked at then. Was it just a plain muitation or could there have been other factors (mother's diet? genetics further back - maybe the recessive genes stay in a N/N dog but aren't seen?).

[Morian]

Originally Posted by Rona

Many CSVs have been DM tested by Daniela at Prague University. All results of vlcaks from Poland (+ Lithuania?, Slovakia?, etc.) tested in Prague fit precisely into the pattern (n/n, n/dm, dm/dm) which indicates high validity of the testing procedures.

I wonder what's the statistical probability that a couple of dogs from the same kennel underwent the mutation?

it means that not only test results must be checked, but authenticity of their pedigrees too (if their parents are really their parents )

[wolfin]

Originally Posted by Rona

Many CSVs have been DM tested by Daniela at Prague University. All results of vlcaks from Poland (+ Lithuania?, Slovakia?, etc.) tested in Prague fit precisely into the pattern (n/n, n/dm, dm/dm) which indicates high validity of the testing procedures.

I wonder what's the statistical probability that a couple of dogs from the same kennel underwent the mutation?

Poland dog are tested in Laboklin too, Lithuanian in OFFA too.

[Rona]

Originally Posted by wolfin

Poland dog are tested in Laboklin too, Lithuanian in OFFA too.

Sure, some were, but:

Many CSVs have been DM tested by Daniela at Prague University.

I meant, wherever the dogs were tested - in Laboklin, OFA or in Prague, by saliva or blood samples, the results fit each other and the whole pattern. What's more - they confirn the earlier tests That's why saying that one lab's more reliable than another makes no sense.
The case considered here could be a mutation, a mistake, a miracle or a lie and the question is - which are more probable, and which less.