DM Testresults

elf · 31-12-2010, 12:01

Quote:

Originally Posted by z Peronówki
It doesn't mean it apply for all other "affected" dogs... It means only that exactly by this "family" there must be something in the genes what "activate" the illness..

This is very likely what's happening, this is the case for many many other diseases or gen traits, i.e. genetic regulatory networks expressivity pattern.

Quote:

Originally Posted by z Peronówki
Because now we miss one VERY important thing... There are lines by CzWs which have SERIOUS problems to move properly already at the age of 2-4 YEARS... And some dogs from these lines have been tested with N/N. So for 100% they do not have DM... They are also HD-free...

My dog has one of these "new disease", she starts walking not properly at the age of 1.5, the scanner showed her disease is related to the central part of bones, this central part -spongy bone-, does not show the correct structure and have too much soft tissus (showed in the scanner as large black parts -some cm long- whereas regular tissus looks light grey). Vets are likely for a genetic causes, but know nothing more about it.

Mikael · 31-12-2010, 13:38

Quote:

Originally Posted by elf

My dog has one of these "new disease", she starts walking not properly at the age of 1.5, the scanner showed her disease is related to the central part of bones, this central part -spongy bone-, does not show the correct structure and have too much soft tissus (showed in the scanner as large black parts -some cm long- whereas regular tissus looks light grey). Vets are likely for a genetic causes, but know nothing more about it.

Very sorry about your dog, is it a CsV ? And how old is she now ?
Did it get worse whit age ?

Best regards / Mikael

Mikael · 31-12-2010, 14:09

On the dogs today that are Affected and ill, can one see anyhing that has any similarities ??? Like high COI % or Line

???

And NO names please !

Very best regards / Mikael

woland77 · 01-01-2011, 15:48

Quote:

Originally Posted by elf

This is very likely what's happening, this is the case for many many other diseases or gen traits, i.e. genetic regulatory networks expressivity pattern.

As plausible, there are several research groups are studying the thing that does not take any responsibility to make assumptions like that. Scientifically still speaking about a " Unkonow trigger" If i'm well informed, the DNA of both brothers are at one of these research bodies, leave to speculate where it is due. Speculating on these assumptions is the best ground where they sprout the witch-hunts.

Shadowlands · 04-01-2011, 12:54

We are going to have our girl tested for DM soon - are there other tests we should consider at the same time (one trip to to the vet to take blood for sending to Laboklin is better than several). What is ED? Are there known eye problems PRA/PLL?

michaelundinaeichhorn · 04-01-2011, 13:05

You need blood for DM and Dwarfism and please also to send for the databank in Bern.
ED is Ellbowdisplasia, that is an x-ray to take when you x-ray for HD.
There are more genetic eye diseases than PRA, normally the specialists (and it should be done by a specialist) check for all of them at once but this should be done in regular terms, we have to do it on a yearly basis in Germany.

Regards
Ina

Shadowlands · 04-01-2011, 14:43

Thanks Ina.

We are based in Bulgaria so it may be difficult to find somewhere to do the regular eye checks you describe, but I will look into it. The ED scan will be done soon and I intend to send blood to Utrecht to scan for Dwarfism. I was thinking of sending extra blood to Laboklin for DNA storage - is this the same or different to the databank in Bern (if different, please can you let me have the details so that I can organise this too).

michaelundinaeichhorn · 04-01-2011, 15:15

Laboklin might also be able to do the dwarfism test, as it is the same test as for German Shepherds. Laboklin stores 2 ml of blood that stays in your property. Bern is doing research on DM and will start a research on our breed as soon as there are enough samples. They store 5ml and more (as much as you send in) that are the property of Bern but will only be used for this project and they do also send blood to other labs if you ask for it. As the storage in Bern is for free I would ask you to send blood to them as well. The storage is cost free.
Sonja Bognarova will publish everything the next days (she promised!). If you need the forms earlier just send me a mail I will send you the forms.

Shadowlands · 04-01-2011, 15:42

I'll ask Laboklin about the Dwarfism test but I thought I had read that they sent the samples to Utrecht. I will certainly send blood to Bern (maybe instead of Laboklin since they want 33 Euros to store the sample - I'd rather spend that on a test than just for storage...)

31-12-2010, 14:09	#3
Mikael Scandinavian Member Join Date: Dec 2007 Location: Stockholm Posts: 1,089	On the dogs today that are Affected and ill, can one see anyhing that has any similarities ??? Like high COI % or Line ??? And NO names please ! Very best regards / Mikael __________________ _________________________________________________ Hronec, Rasty, Zilja Kennel, Wolfdog of Sweden* http://kennelwolfdogofsweden.vpsite.se/Home.html http://www.facebook.com/pages/Wolfdo...53067971392916

04-01-2011, 12:54	#5
Shadowlands Junior Member Join Date: Nov 2009 Location: Vidin Posts: 391	We are going to have our girl tested for DM soon - are there other tests we should consider at the same time (one trip to to the vet to take blood for sending to Laboklin is better than several). What is ED? Are there known eye problems PRA/PLL?

04-01-2011, 13:05	#6
michaelundinaeichhorn Senior Member Join Date: Sep 2003 Location: Bad Dürkheim Posts: 2,249	You need blood for DM and Dwarfism and please also to send for the databank in Bern. ED is Ellbowdisplasia, that is an x-ray to take when you x-ray for HD. There are more genetic eye diseases than PRA, normally the specialists (and it should be done by a specialist) check for all of them at once but this should be done in regular terms, we have to do it on a yearly basis in Germany. Regards Ina

04-01-2011, 14:43	#7
Shadowlands Junior Member Join Date: Nov 2009 Location: Vidin Posts: 391	Thanks Ina. We are based in Bulgaria so it may be difficult to find somewhere to do the regular eye checks you describe, but I will look into it. The ED scan will be done soon and I intend to send blood to Utrecht to scan for Dwarfism. I was thinking of sending extra blood to Laboklin for DNA storage - is this the same or different to the databank in Bern (if different, please can you let me have the details so that I can organise this too).

04-01-2011, 15:15	#8
michaelundinaeichhorn Senior Member Join Date: Sep 2003 Location: Bad Dürkheim Posts: 2,249	Laboklin might also be able to do the dwarfism test, as it is the same test as for German Shepherds. Laboklin stores 2 ml of blood that stays in your property. Bern is doing research on DM and will start a research on our breed as soon as there are enough samples. They store 5ml and more (as much as you send in) that are the property of Bern but will only be used for this project and they do also send blood to other labs if you ask for it. As the storage in Bern is for free I would ask you to send blood to them as well. The storage is cost free. Sonja Bognarova will publish everything the next days (she promised!). If you need the forms earlier just send me a mail I will send you the forms.

04-01-2011, 15:42	#9
Shadowlands Junior Member Join Date: Nov 2009 Location: Vidin Posts: 391	I'll ask Laboklin about the Dwarfism test but I thought I had read that they sent the samples to Utrecht. I will certainly send blood to Bern (maybe instead of Laboklin since they want 33 Euros to store the sample - I'd rather spend that on a test than just for storage...)