DM test for CsW is available!

[mijke]

Originally Posted by elf

In fact I was thinking about what would be a clever breeding program regarding DM for CSV, because if one looks at OFA statistic for GSD here it is ( http://www.offa.org/dnateststats.html ):

GERMAN SHEPHERD DOG
CLEAR 213 46%
CARRIER 151 33%
AT RISK 98 21%
TOTAL ABNORMAL 249 54%
TOTAL TESTED 462

So 54% abnormal...

Hmmmm.. I think that is a bit complicated on this moment.

We just did start with testing and don't have a clue how many dogs will be carrier or affected.
Besides that it is know that not all affected ones become ill between 8 and 10years. Some of them have other problems or die before they have DM problems. And with other dogs the problems develop when they are 13 years or older.

The research of Missouri recommends:
We recommend that dog breeders take into consideration the DM test results as they plan their breeding programs; however, they should not over-emphasize this test result. Instead, the test result is one factor among many in a balanced breeding program.

And I agree with this! We should not over react on DM.
There will appear more diseases (and tests for this) in future.

Most of the Carriers and Affected dogs will have also good genes for the future of the breed! And we can't afford to exclude all these dogs for the gene pool of the breed.

We need time to reduce this disease!
So maybe we can choose to make combinations Affected x Free and Carrier x Free (and of course Free x Free ).
Then you don't create Affected ones any more
And yes indeed than you are still spreading the defect gene in the population.
But when you want to exclude all the Carriers and Affected ones, you can wait for other new genetic diseases!

But I hope everyone realizes also that although when we don't exclude dogs, it is very important to test as many dogs as we can!

A bit of topic:
After I did receive some questions about DNA tests for MD, I also want to explain another thing.

The test that is validated for CsW is based on MDO1 gene. This is the same test that is developed in Missouri (Click HERE for more info about all Missouri research)

Besides this on internet is also to find info about the DM Flash test 1101 (of dr Clemmons) in Florida. But there was never a scientific publication about this test, and I was informed by specialist that this test is not trustful.

[jmvdwiel]

Hi here again some video material I found and did want to share with you all. Those video's were made before the DNA test was available, but wil provide you with some more information about DM.
http://www.akcchf.org/video/viewer.cfm?vid=1

And when you have a dog with DM here is a video how to care for this dog, I don't think I would go that far with a dog of mine.. but that is something that every owner has to deside for himself.
http://www.akcchf.org/video/viewer.cfm?vid=2

So I think we have the tool now to get rid of this problem in the future, see for yourself and again... wise decisions to be made.

[Mikael]

Thanks

Poor poor dogs

I will test all my dogs for DM

Very best regards / Mikael

[jmvdwiel]

more video materials at
http://video.google.nl/videosearch?h...ed=0CB0QqwQwAw#

you can even give your dog a nice wheelchair until her frontleg wil collaps also , so delay of execution

[GalomyOak]

Originally Posted by mijke

A bit of topic:
After I did receive some questions about DNA tests for MD, I also want to explain another thing.

The test that is validated for CsW is based on MDO1 gene. This is the same test that is developed in Missouri (Click HERE for more info about all Missouri research)

Besides this on internet is also to find info about the DM Flash test 1101 (of dr Clemmons) in Florida. But there was never a scientific publication about this test, and I was informed by specialist that this test is not trustful.

Thanks Mijke!

On my next pay check, I will test at least a couple of dogs, and then the other two on the paycheck after that. The Missouri test is better for another reason - in the US (or anywhere), the results are displayed on the OFA database, along with all of our dog's other information (except for PennHip results - hopefully UPenn will have an online database someday). The cost for this test is US$65.

Marcy

[draggar]

A good friend of ours lost her GSD from DM. One year he was #25 in the world for schutzhund and about 18-24 months later he had to be put down. The DM came into his system quickly and didn't hold back at all. One day he was a little sensitive in his foot and about 8 months later the owner had to put him down. We were all devastated.

The good news is that even a dog with the A/A gene, if bred to a N/N dog the puppies would be, at worst, carriers. If a carrier (N/A) is bred to a N/N dog, then all the dogs will be N/N.

It's sad to see so many GSD breeders refuse to test their dogs, "I don't worry, DM isn't in my lines". How can you tell if you've never tested them?

The test is around $65 (US) and run by OFA - well worth the price. We DM tested our GSD and she's N/N.

[jmvdwiel]

If a carrier(N/A is bred to a N/N dog, than half of the dogs wil be N/N and half wil be N/A (so all healthy!!)

If a A/A is crossed with an N/N all dogs wil be cariers !!!! (so all healthy) a little nuance difference.

Originally Posted by draggar

The good news is that even a dog with the A/A gene, if bred to a N/N dog the puppies would be, at worst, carriers. If a carrier (N/A) is bred to a N/N dog, then all the dogs will be N/N.

[draggar]

Let me look into it. I might have a contact in UFl in Ganesville, or have a contact who has a contact there.

[jmvdwiel]

http://www.k-9cart.com/Pet-Wheelchai...eelchairs.html

I stole a little bit of text from this site and supplemented it with my own

All dogs carry two copies of the SOD1 gene. The genetic testing results will tell you if the mutation is present and if so whether one or both genes is involved. Possible results:
· Normal/Normal (N/N): Both genes are normal and do NOT carry the defect in the SOD1 gene. In the seven dog breeds that the University of Missouri has extensively studied, no dog that has two normal genes has ever had a confirmed diagnosis of DM. If used in a dog breeding program, N/N dogs will pass the normal gene onto the puppies. Thus, the puppies should be free of DM also.
· Abnomal/Normal (A/N): This dog has one normal and one abnormal gene and is called a "carrier." Carrier dogs in the seven breeds studied by the University of Missouri have never had a confirmed case of DM. However, as a carrier, this dog could transfer the abnormal gene to the puppies.
· Abnormal/Abnormal (A/A): This dog has two abnormal copies of the SOD1 gene and is at risk for developing DM. All dogs that have had confirmed cases of DM that were tested by the University of Missouri in their study also had two abnormal genes. However, not all dogs that will test positive (A/A) and be at risk will show signs of DM. In part, this is because DM is a disease of middle to old age. So younger at risk dogs may not look normal and not show signs until much older. Some of the at risk dogs may never reach an old enough age to show signs. But all dogs that are A/A will pass on one copy of the genetic defect to their puppies.

SORRY BUT ALL THE DOTS SHOULD BE OPEN SPACES BUT THAT DIDN"T WORK

Possible crossings:
NN X NN Male and female have two normal genes: male: N and N female NN
.....N.......N
N ..NN...NN
N...NN...NN so all normal dogs

NN X AN or AN X NN Male or female has to normal genes and the other one is a Carrier
.....A.....N
N..AN...NN
N..AN...NN so half is AN (carier) and half is NN (normal)


NA X NA male and female are cariers
........N.......A
N.....NN....NA
A.....NA....AA , so 1/4 NN (normal) , 1/2 NA (carier), and 1/4 AA(affected)

AA X AN or AN X AA Male or female has 2 Affected genes and the other one is a carier
.....A.....A
A ..AA..AA
N...AN..AN so half AA (affected) and half AN (carier)


AA X NN or NN X AA Male or female is affeced and th other one is Normal
.....A....A
N...NA...NA
N...NA...NA so al wil be cariers and not sick

AA x AA Male and female have two affected genes
.....A....A
A..AA ..AA
A ..AA ..AA so all dog wil be AA (affected)

[draggar]

Fred got back to me with "Here's my latest with DM" (and asked me to put it on his site):
http://www.fredlanting.org/2010/02/t...athy%E2%80%9D/

While I didn't see the article go into the actual genetics, your way (jmvdwiel) makes more sense (my way would have had the disease elimiated naturally unless there was either very bad luck or far more A/A dogs than believed).

Still - this means an A/A lines could have the DM "bred out" in two generations.

A/A to an N/N - All "carriers"
N/A to another N/A - half carriers, half not carriers (no DM).

It's sad that so many GSD breeders refuse to test for DM but claim "it's not in my lines!" (yet how do you know if you don't test?). Any dog that we consider to breed to Kiri has to be DM tested.

Originally Posted by GalomyOak

Thanks Mijke!

On my next pay check, I will test at least a couple of dogs, and then the other two on the paycheck after that. The Missouri test is better for another reason - in the US (or anywhere), the results are displayed on the OFA database, along with all of our dog's other information (except for PennHip results - hopefully UPenn will have an online database someday). The cost for this test is US$65.

Marcy

Did you test Luna's parents? What were the results?

$65 is well worth the test.