Pituitary Dwarfism test for CsW is available!

[mijke]

There were 30 CsW’s tested for Pituitary Dwarfism.
Of these 30 CsW’s were 6 carriers of the mutated gen.

On the site wolfdog-healthinfo.org you can find the test results. Click HERE

Because 1/5 of the tested dogs was carrier, it is very useful to test more CsW’s!
Only then we can see how this disease is spread in the population

And it is entirely useful for breeders to test for breeding!
And especial when you want to breed with offspring, brother/ sisters, parents and ancestors of carriers of dwarfism gen.

But even when a male or female is carrier, it is no problem to breed with them!

Not any carrier has to excluded for breeding!

Only don’t make combinations of carrier x carrier!

On top of this topic you can find how an owner can test a CsW for Pituitary Dwarfism.
And you also can find there a link for the blood sample form.

[Rona]

Mijke, I have a question, maybe naive, but I had classes in genetics only at school, and that was very long time ago.

Am I right assuming that if a carrier is matched with a carrier, absolutely every pup born from this match is a carrier of the gene, only most of them do not simply develop the illness... ?

In that case there is no need to test parents and full sibilings of dwarfs, because they would be 100% carriers.

But there is definitely sense in testing first ONE parent of a carrier (if he/she's free, there is no need to test the other one) or/and half-sibilings of carriers, because some of them might have taken the gene after their carrier-mother or carrier-father and some not. Does my reasoning make sense?

I'm asking, because if breeders openly declared in which litters there were dwarf puppies born, some owners would not have to test their dogs to learn the positive results (ie dwarf+).

On the other hand I suppose sometimes it's hard to recognize the true reason of a very young puppy's death - it could be either dwarfism or some other genetic or inborn malformation.

[michaelundinaeichhorn]

I am not Mijke but will answer.
If you declare a carrier as p(ositive for dwarf)/n(negative for dwarf), it means that in an egg or a sperm there is only one p or one n, in combining two carriers you get the possible pairings p/p, p/n and n/n. what means you can get negativ (no dwarf gene) dogs by pairing two carriers. The only problem is you might get some p/p out of this pairing.

Ina

[jefta]

so, all puppys after parents n/n + n/n get a certificate without testing?

[saschia]

Originally Posted by jefta

so, all puppys after parents n/n + n/n get a certificate without testing?

In theory, puppies after clear parents are also clear, but there is always very low, but not nonexistent, probability of spontaneous mutation in the gene. Bad thing is, this mutation would probably not be recognized by the test. But this is true for any genetic illness. And the probability is so low that it can be ignored for most purposes (unless dwarves start to be born after clear parents).

In my opinion, to get a certificate, the pups should either be tested for the gene itself, or for the paternity of the proclaimed parents (which might be more economic if the parents have certificates for several genetic disorders - but I am not sure if it would be accepted).

[Rona]

Originally Posted by michaelundinaeichhorn

I am not Mijke but will answer.
If you declare a carrier as p(ositive for dwarf)/n(negative for dwarf), it means that in an egg or a sperm there is only one p or one n, in combining two carriers you get the possible pairings p/p, p/n and n/n. what means you can get negativ (no dwarf gene) dogs by pairing two carriers. The only problem is you might get some p/p out of this pairing.

Ina

This means each dog should be checked individually wheather it is nn, np or pp. No shortcuts , as usually in life
Thanks for the explanation, Ina.

[jefta]

I think its good time for discusion about N/N puppys (after parents,no tested) before? first litter is born.

My arguments:

pro-
*economy-genetic test is expensive (more than 100 E), so what is a sense to test dogs which are for 99,9% free?
*motivation for breeders to test own dogs-extra incentive to buy the puppys or use stud dogs.

contra-
*discrimination breeders/stud dog owners which can't get cetificat because of using carrier (negative occurrence in so small populacion)

[saschia]

Originally Posted by jefta

pro-
*economy-genetic test is expensive (more than 100 E), so what is a sense to test dogs which are for 99,9% free?

This is true - and there is very low probability that a new mutation would be safely recognized by the existing test.
But you would still need to test them at least for the parentage. That would actually be advantageous in my opinion, as paternity and maternity certificates would ensure no cheating in CW/SW crossing for example...

But back to the original topic - in todays situation, unfortunately, the most responsible breeders, that means the ones who invest in all the health tests available, and do not hide the results, are the ones that would actually be disadvantaged, unless the buyers are very well educated in these problem and actively select only puppies from responsible owners and are prepared to pay more for that certificates. Which is unfortunately not true yet. Most of buyers are newcomers to the breed and most of them only want a dog for friendship and fun and prefer to pay less and to buy locally. Or they want dogs for shows and buy only after champions, even if those champions got their titles from referees who have never seen a wolfdog in their lives.

[Hanka]

Because we know, now exist "new, fresh" dwarf pups in litters, I want write to all breeders which have these pups in litter: PLEASE contact Mijke and help us to collect blood.
Don´t kill pups when you will know it- it is dwarf - and help us.
Maybe in this moment the breeders does not know it, but they can see it a few days or weeks later.
Thanks Hanka

[Backman]

DNA test for pituary dwarfism:

Blazy de la Louve Blanche
Dream Wolf de la Louve Blanche
Crying Wolf Luka
Forever Wolf Arctic Hero
Forever Wolf Arctic Angel
Forever Wolf Arctic Storm

ALL CLEAR OF THE MUTATION !

Jenny

[Hanka]

Dero Sotis - clear of mutation

[*Satu]

Baron spod Dumbiera - clear of mutation
Wolfsirius Sleeping Storm -clear of mutation
Basior Jantarowa Wataha - clear of mutation
Ikala spod Dumbiera - clear of mutation
Elys spod Dumbiera - carrier of mutation

so Taabernakkelin K-litter will be clear of mutation

rest 2 Finlandya and Andradite I give later...

[leila]

Gunner Malý Bysterec - CLEAR of the mutation!